A 57-year-old man with a history of diabetes mellitus and alcohol consumption was referred to the hand surgery unit owing to contractures of fingers of both hands. He reported that ... (Source: New England Journal of Medicine)
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Sunday, September 27, 2009
Expression of matrix metalloproteinases and their inhibitors in cords and nodules of patients with Dupuytren�s disease
Conclusions The balance between MMPs and their natural inhibitors is disturbed in patients with Dupuytren�s disease. The decrease in MMP-to-TIMP expression can cause increased synthesis and deposition of collagen, leading to palmar fibromatosis. The high expression of MMP2 may represent an unsuccessful attempt to reduce collagen deposition. In the future, a treatment that downregulates TIMPs but increases the activity of MMPs may be an appropriate therapy for Dupuytren�s disease. Content Type Journal ArticleCategory Orthopaedic SurgeryDOI 10.1007/s00402-008-0726-3AuthorsDietmar Ulrich, Aachen University of Technology Department of Plastic Surgery, Hand Surgery, Burn Unit, University Hospital, Medical Faculty of the University of Technology Pauwelsstrasse 30 5207...
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Thursday, September 24, 2009
Cottage Cheese Making Kit - Makes 30 Pounds
 | $29.99 End Date: Sunday Oct-11-2009 8:36:32 PDT Buy It Now for only: US $29.99 Buy it now | Add to watch list |
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Monday, September 21, 2009
Nonsurgical Treatment for Dupuytren Contracture with Collagenase
(Source: Physician's First Watch current issue)
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Friday, September 18, 2009
Cryptosporidiosis in paediatric renal transplantation
Abstract Diarrhoea in transplantation may be secondary to infectious agents and immunosuppressive drugs. The use of combined immunosuppressive drugs increases the incidence of infectious diarrhoea. We retrospectively collected all diarrhoea episodes during a 3-year period in 199 pediatric renal transplant recipients, including 47 patients receiving a kidney transplant during this period. We diagnosed 64 diarrhoea episodes (32% of the patients, 10.7% per year). Fourteen diarrhoea episodes could be attributed to the immunosuppressive treatment, and 12 remained without diagnosis. Nineteen patients (<10%) receiving mycophenolic acid (MPA) developed diarrhoea, 14 of whom had episodes attributable to the immunosuppressive treatment. Reducing the MPA dose or switching to anoth...
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Complete Information on Dupuytren's contracture with Treatment and Prevention
Dupuytren's contracture is a reasonably popular disorder of the fingers. Men are more possible than women to produce dupuytren's contracture. A tendency to produce dupuytren's contracture may be passed through families. It's more common in older adults, usually developing in people in their 50s and 60s. Although the precise cause of dupuytren's contracture hasn't been identified, a number of factors are believed to increase the risk of the disease. Dupuytren's contracture is more common in people who've had epilepsy for many years. Some doctors believe the risk may come from the anticonvulsant medications that some people with epilepsy take. It is associated with smoking and drinking. People with type 1 diabetes or type 2 diabetes have an increased risk of tender tissue lumps on the palms of the hands, but they usually don't develop contracted fingers.
Dupuytren's contracture complicates mundane activities such as placing your hands in your pockets, putting on gloves or shaking hands. Dupuytren's contracture is more popular in whites of northern european heritage. The condition rarely affects people of color. Dupuytren's contracture often affects both hands, though one hand is usually affected more severely than the other. Dupuytren's contracture usually doesn't cause pain and often doesn't interfere with your ability to carry out everyday tasks. Dupuytren's contracture can make it difficult to perform certain functions using your hand. Since the thumb and index finger aren't usually affected, many people don't experience much inconvenience or disability. The ring and the small fingers are affected more often than the others, although any or all of the digits may be involved.
Dupuytren's contracture is seldom traumatic, though sometimes the bumps of tissue on your palm can be susceptible to affect. Dupuytren's contracture normally begins as a thickening of the rind on the palm of your hand. In late stages of dupuytren's contracture, cords of tissue kind under the rind on your palm. Cords may extend up to your fingers. As these cords tighten, your fingers may be pulled toward your palm, sometimes severely. Dupuytren's contracture usually progresses slowly, over several years. Occasionally it can develop over weeks or months. As Dupuytren's contracture progresses, the skin on the palm of your hand may appear dimpled. In some people it progresses steadily and in others it may start and stop. However, dupuytren's contracture never regresses. Patients with this condition usually seek medical advice for cosmetic reasons or the loss of use of their hand.
There is no manner to halt or heal the trouble. It is not harmful. Treatment of dupuytren's disease with reduced vitality x-rays may heal morbus dupuytren on a lengthy condition, specifically if applied in earlier stages of the disease. If a painful lump is present, an injection may help diminish the pain. Surgery is recommended when the inability to straighten the fingers significantly limits hand function. Surgery for dupuytren's contracture divides or removes the thickened bands to help restore finger motion. Risks of surgery include injury to nerves and blood vessels and infection. Some swelling and soreness are expected, but severe problems are rare. Elevating the hand after surgery and gently moving the fingers helps to minimize pain, swelling, and stiffness. Surgery does not always cure the disease, which may progress gradually and sometimes recur over time.
Dupuytren's contracture complicates mundane activities such as placing your hands in your pockets, putting on gloves or shaking hands. Dupuytren's contracture is more popular in whites of northern european heritage. The condition rarely affects people of color. Dupuytren's contracture often affects both hands, though one hand is usually affected more severely than the other. Dupuytren's contracture usually doesn't cause pain and often doesn't interfere with your ability to carry out everyday tasks. Dupuytren's contracture can make it difficult to perform certain functions using your hand. Since the thumb and index finger aren't usually affected, many people don't experience much inconvenience or disability. The ring and the small fingers are affected more often than the others, although any or all of the digits may be involved.
Dupuytren's contracture is seldom traumatic, though sometimes the bumps of tissue on your palm can be susceptible to affect. Dupuytren's contracture normally begins as a thickening of the rind on the palm of your hand. In late stages of dupuytren's contracture, cords of tissue kind under the rind on your palm. Cords may extend up to your fingers. As these cords tighten, your fingers may be pulled toward your palm, sometimes severely. Dupuytren's contracture usually progresses slowly, over several years. Occasionally it can develop over weeks or months. As Dupuytren's contracture progresses, the skin on the palm of your hand may appear dimpled. In some people it progresses steadily and in others it may start and stop. However, dupuytren's contracture never regresses. Patients with this condition usually seek medical advice for cosmetic reasons or the loss of use of their hand.
There is no manner to halt or heal the trouble. It is not harmful. Treatment of dupuytren's disease with reduced vitality x-rays may heal morbus dupuytren on a lengthy condition, specifically if applied in earlier stages of the disease. If a painful lump is present, an injection may help diminish the pain. Surgery is recommended when the inability to straighten the fingers significantly limits hand function. Surgery for dupuytren's contracture divides or removes the thickened bands to help restore finger motion. Risks of surgery include injury to nerves and blood vessels and infection. Some swelling and soreness are expected, but severe problems are rare. Elevating the hand after surgery and gently moving the fingers helps to minimize pain, swelling, and stiffness. Surgery does not always cure the disease, which may progress gradually and sometimes recur over time.
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